Table 3 Outcomes of one-way sensitivity analysis in WHO coverage targets are achieved by 2030
From: The macroeconomic burden of hepatitis C and the economic benefit of accelerated investments in China
cumulative incident CHC(millions) | cumulative incident HCC(millions) | cumulative HCV attributable deaths(millions) | cumulative HCV attributable DALYs(millions) | cumulative direct costs(billions) | cumulative productivity losses(billions) | macroeconomic burden(trillions) | ICER (year achieved ICER < 0) | NEB (year achieved) | |
|---|---|---|---|---|---|---|---|---|---|
Base Case | 3.10 | 0.52 | 0.77 | 6.90 | 69.71 | 72.02 | 0.56 | 2037 | 2034 |
Mortality worst case | 3.10 | 0.52 | 0.79 | 6.96 | 69.10 | 73.30 | 0.57 | 2037 | 2034 |
Mortality best case | 3.11 | 0.53 | 0.76 | 6.84 | 70.85 | 70.62 | 0.55 | 2037 | 2034 |
Treatment Effectiveness worst case | 3.11 | 0.52 | 0.78 | 6.93 | 70.22 | 72.43 | 0.56 | 2037 | 2034 |
Treatment Effectiveness best case | 3.09 | 0.52 | 0.77 | 6.92 | 69.85 | 72.25 | 0.56 | 2037 | 2034 |
Annual Ab-hcv and hcv RNA costs halved | 3.10 | 0.52 | 0.77 | 6.90 | 68.61 | 72.02 | 0.56 | 2037 | 2034 |
Annual Ab-hcv and hcv RNA costs double | 3.10 | 0.52 | 0.77 | 6.90 | 71.64 | 72.02 | 0.56 | 2037 | 2034 |
Annual DAA costs halved | 3.10 | 0.52 | 0.77 | 6.90 | 62.24 | 72.02 | 0.56 | 2033 | 2031 |
Annual DAA costs double | 3.10 | 0.52 | 0.77 | 6.90 | 84.39 | 72.02 | 0.56 | 2045 | 2038 |
Annual F0-4 management costs halved | 3.10 | 0.52 | 0.77 | 6.90 | 49.38 | 72.02 | 0.56 | 2045 | 2036 |
Annual F0-4 management costs doubled | 3.10 | 0.52 | 0.77 | 6.90 | 110.11 | 72.02 | 0.56 | 2032 | 2032 |
Annual DC and HCC management costs halved | 3.10 | 0.52 | 0.77 | 6.90 | 63.45 | 72.02 | 0.56 | 2037 | 2034 |
Annual DC and HCC management costs doubled | 3.10 | 0.52 | 0.77 | 6.90 | 81.96 | 72.02 | 0.56 | 2037 | 2034 |
0% disease management | 3.10 | 0.52 | 0.77 | 6.90 | 16.78 | 72.02 | 0.56 | $2392 | 2039 |
50% disease management | 3.10 | 0.52 | 0.77 | 6.90 | 122.45 | 72.02 | 0.56 | 2033 | 2032 |
0% discount | 3.10 | 0.52 | 0.77 | 6.90 | 69.62 | 72.02 | 0.56 | 2037 | 2034 |
5% discount | 3.10 | 0.52 | 0.77 | 6.90 | 69.62 | 72.02 | 0.56 | 2037 | 2034 |