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Table 3 RERI and AP for additive interaction between BMI categories and genetic riska

From: Joint and interactive associations of body mass index and genetic factors with cardiovascular disease: a prospective study in UK Biobank

BMI categories

Genetic Riskb

Intermediate

High

P for overall test

RERIc(95%CI)

APc(95%CI)

RERIc(95%CI)

APc(95%CI)

RERI

AP

HTN

 Overweight (25.0–29.9 kg/m2)

0.07 (0.02–0.13)

0.04 (0.01–0.07)

0.22 (0.16–0.28)

0.09 (0.07–0.12)

 < 0.001

 < 0.001

 Obesity (≥ 30.0 kg/m2)

0.27 (0.18–0.36)

0.08 (0.05–0.11)

0.53 (0.43–0.62)

0.13 (0.11–0.16)

AF

 Overweight (25.0–29.9 kg/m2)

0.02 (-0.09–0.13)

0.01 (-0.06–0.08)

0.19 (0.07–0.31)

0.08 (0.03–0.13)

 < 0.001

 < 0.001

 Obesity (≥ 30.0 kg/m2)

0.28 (0.13–0.42)

0.10 (0.05–0.16)

0.67 (0.51–0.83)

0.19 (0.14–0.23)

CHD

 Overweight (25.0–29.9 kg/m2)

0.03 (-0.06–0.12)

0.02 (-0.04–0.08)

0.16 (0.07–0.26)

0.08 (0.03–0.13)

 < 0.001

 < 0.001

 Obesity (≥ 30.0 kg/m2)

0.04 (-0.08–0.16)

0.02 (-0.04–0.07)

0.37 (0.25–0.49)

0.13 (0.09–0.18)

Stroke

 Overweight (25.0–29.9 kg/m2)

0.06 (-0.06–0.18)

0.05 (-0.05–0.15)

0.08 (-0.04–0.21)

0.07 (-0.03–0.17)

0.347

0.368

 Obesity (≥ 30.0 kg/m2)

-0.04 (-0.19–0.11)

-0.03 (-0.15–0.08)

0.07 (-0.08–0.21)

0.05 (-0.06–0.15)

HF

 Overweight (25.0–29.9 kg/m2)

-0.01 (-0.14–0.12)

-0.01 (-0.11–0.10)

0.16 (0.03–0.29)

0.11 (0.02–0.20)

0.073

0.072

 Obesity (≥ 30.0 kg/m2)

0.05 (-0.14–0.23)

0.02 (-0.06–0.09)

0.12 (-0.07–0.30)

0.05 (-0.03–0.12)

  1. Abbreviations: AF atrial fibrillation, AP the attributable proportion due to interaction, BMI body mass index, CHD coronary heart disease, CI confidence interval, HF heart failure, HTN hypertension, PRS polygenic risk score, RERI the relative excess risk due to interaction
  2. aAdjusted for age, sex, ethnicity, education, employment status, household income, smoking status, drink frequency, healthy diet, IPAQ, Townsend deprivation index, the top two pollution principal components, and the top four principal components of ancestry and genotyping batch. bDefined by polygenic risk score; low (lowest tertiles), intermediate (second tertiles) and high (highest tertiles). cTo estimate RERI and AP, the normal weight (< 25.0 kg/m2) and the lowest genetic risk groups were the reference categories
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BMC Public Health

ISSN: 1471-2458

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